PDRN

PDRN Explained: Advanced Support For Skin Repair

PDRN, short for polydeoxyribonucleotide, is a regenerative skincare ingredient recognised for its ability to support skin recovery and barrier resilience. Often associated with advanced aesthetic treatments, PDRN is now formulated into serums and creams designed to calm, hydrate and visibly improve compromised or ageing skin.

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Pink tube of Medicube hair product on a white backgroundMedicube PDRN Booster Gel 300ml
Medicube PDRN Booster Gel 300ml

£16.19 £18.00 10% offsaving
Medicube pink toner bottle on a white backgroundMedicube PDRN Pink Cica Soothing Toner 250ml
Medicube PDRN Pink Cica Soothing Toner 250ml

£12.74 £17.00 25% offsaving
Medicube serum mist bottle on a white backgroundMedicube PDRN Pink Glutathione Serum Mist 100ml
Medicube PDRN Pink Glutathione Serum Mist 100ml

£14.99 £20.00 25% offsaving

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Medicube PDRN Pink Peptide Serum 30mlMedicube PDRN Pink Peptide Serum 30ml
Medicube PDRN Pink Peptide Serum 30ml

£14.24 £19.00 25% offsaving
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Pink tube of medicube cream on a white background
Medicube PDRN Pink Hyaluronic Moisturizing Cream 50ml

£15.29 £17.00 10% offsaving
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Medicube PDRN Pink Collagen Gel Mask (4EA)Medicube PDRN Pink Collagen Gel Mask (4EA)
Medicube PDRN Pink Collagen Gel Mask (4EA)

£11.89 £17.00 30% offsaving
PDRN

About PDRN

Discover The Science Behind PDRN

PDRN, or polydeoxyribonucleotide, is a DNA-derived ingredient recognised for its regenerative properties in skincare. Commonly sourced from salmon, it is valued for supporting skin repair, improving resilience and encouraging a smoother, more refined appearance.

Find Your Perfect Barrier Supporting Formula

From lightweight PDRN serums to nourishing creams, these advanced formulations help calm stressed skin, reinforce the barrier and promote visible renewal. Ideal for compromised, sensitive or ageing skin, PDRN works alongside hydrating and strengthening ingredients for balanced results.

Personalised Advice On PDRN Skincare

If you’re unsure whether PDRN is right for your skin, you can take our free online skin test, read our blog for expert guidance, or contact us for personalised support from our skincare specialists.

Expert Tip for Using PDRN

"Apply your PDRN serum to clean, slightly damp skin before moisturiser to maximise absorption and support barrier recovery. This allows the regenerative ingredients to work efficiently while sealing in hydration with a nourishing cream. Consistent use is key when targeting compromised or ageing skin. A balanced routine will help maintain strength, comfort and visible improvement over time."

– Kimberley, Clinic & Customer Experience Manager

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Support Stronger, Healthier Looking Skin With PDRN

Expertly formulated PDRN serums and creams designed to promote skin repair, reinforce the barrier and improve overall texture. Ideal for stressed, sensitised or post-treatment skin, these advanced formulas combine innovation with gentle, restorative care.
Medicube serum mist bottle on a white backgroundMedicube PDRN Pink Glutathione Serum Mist 100ml
Medicube PDRN Pink Glutathione Serum Mist 100ml

£14.99 £20.00 25% offsaving
Medicube pink toner bottle on a white backgroundMedicube PDRN Pink Cica Soothing Toner 250ml
Medicube PDRN Pink Cica Soothing Toner 250ml

£12.74 £17.00 25% offsaving
Pink tube of Medicube hair product on a white backgroundMedicube PDRN Booster Gel 300ml
Medicube PDRN Booster Gel 300ml

£16.19 £18.00 10% offsaving

Frequently Asked Questions

What does PDRN stand for?

PDRN stands for polydeoxyribonucleotide. It is a DNA-derived ingredient, commonly sourced from salmon, used in skincare for its regenerative and skin-repairing properties.

What does PDRN do for the skin?

PDRN helps support skin recovery, improve barrier resilience and promote a smoother, more even-looking complexion. It is often used to calm stressed or compromised skin.

Is PDRN good for damaged skin barrier?

Yes, PDRN is frequently included in barrier repair skincare as it helps reinforce skin resilience and support recovery after environmental stress or aesthetic treatments.

Can PDRN help with anti-ageing concerns?

PDRN is associated with skin renewal and improved elasticity, making it beneficial for targeting fine lines, dullness and loss of firmness.

Is PDRN suitable for sensitive skin?

Many PDRN formulations are designed to be gentle and calming, making them suitable for sensitive or redness-prone skin types. Always patch test first.

Can PDRN be used with retinol or acids?

PDRN can often be paired with active ingredients like retinol or exfoliating acids to support recovery and minimise irritation. Introduce gradually and follow professional guidance.

Is PDRN the same as hyaluronic acid?

No, hyaluronic acid primarily focuses on hydration, while PDRN is positioned as a regenerative ingredient that supports repair and skin renewal. They can complement each other in a routine.